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Thomas Pelham-Holles, Duke of Newcastle – Returning to office with Pitt the Elder as Southern Secretary, this government helped steer Britain to ultimate victory over France and Spain during the Seven Years’ War.
John Stuart, 3rd Earl of Bute – A favourite of George III, he was the first Scot to hold the top office.
Lord Fredrick North – Led Great Britain into the American War of Independence (1775).
Although blamed for Britain’s subsequent defeat, many of the military operations were hampered by infighting within the British high command in North America.
During the Seven Years’ War, he was blamed for the loss of Minorca and was replaced by the Duke of Devonshire.
William Cavendish, Duke of Devonshire – In a government effectively controlled by Pitt the Elder, Devonshire’s administration was brought to end following the dismissal of Pitt by the king, it was replaced by the Second Newcastle Ministry.
Henry Addington, 1st Viscount Sidmouth – Although the Treaty of Amiens in 1802 temporarily halted the hostilities between the French Republic and Great Britain, the uneasy truce ended in May 1803 when Britain again declared war on France.
William Wyndham Grenville, 1st Baron Grenville – The youngest son of George Grenville, during his ministry the Slave Trade Act 1807: abolished the slave trade in the British Empire.
He resigned when the king refused to accept Catholic emancipation.
His short time in office was beset by disputes between warring factions within his ministry. Spencer Perceval – With economic depression and Luddite agitation at home, and the threat of Napoleon in Europe, his administration was divided and repressive.
The only British Prime Minister ever to be assassinated, he was shot in the lobby of the House of Commons by a bankrupt who blamed the government for his misfortune.
Walpole resigned as a consequence of his perceived mis-handling in dealing with the War of Jenkins’ Ear.
Henry Pelham – During his time in the post he oversaw the the British involvement in the War of the Austrian Succession in 1744-48, the 1745 Jacobite Rising and the adoption of the Gregorian calender. Thomas Pelham-Holles, Duke of Newcastle – Assumed the office of Prime Minister just 10 days after the death of his brother Henry Pelham.
William Petty, 2nd Earl of Shelburne – Britain’s first Irish-born Prime Minister, a former general he was in office at the time of the Treaty of Paris which officially ended the American War of Independence.